Technical Bulletin

Research Trend
AAV – The king of viral vectors?
Adeno-associated virus (AAV) has recently been surging in popularity as a vector system. The recent wave of gene therapy successes and powerful new genome editing technologies, such as CRISPR/Cas9, have increased public and scientific awareness of t... Read More ›
Research Trend
Vectors on the brain
The nervous system presents several unique challenges that make it a difficult system to study experimentally. At a structural level, the brain has a complexity that is orders of magnitude greater than other organs, and even the peripheral nervous s... Read More ›
Research Trend
Optogenetics in the clinic
Ever since the cloning of channelrhodopsin-2 (ChR2), there has been an explosion of interest in applying optogenetic methods to all aspects of neuroscience1. Initially, ChR2 was used to control neuronal activity in vitro2,3, and shortly thereafter in... Read More ›
Research Trend
Lentivirus “cure” for a ALD
For decades, new innovations in stem cell biology and genetic manipulation have driven a wave of proposed treatments based on these technologies. Although there has been intense speculation and expectation about when and how these methods will finall... Read More ›
Latest Discovery
Treating alcoholism with gene therapy
Alcoholism is a complex disease affecting hundreds of millions of people worldwide1. Despite having devastating consequences on physical and mental health, and indirectly impacting families and society, treatment options are limited and often ineffec... Read More ›
Research Trend
In vivo reprogramming with viral vectors
Although multicellular organisms are made up of many cell types, all with essentially identical genomes, cells rarely interconvert between cell types. Once a cell acquires a specific cell fate, it generally does not assume the phenotype of an alternate cell type.... Read More ›
Research Trend
shRNA screens lead to major discoveries
Loss-of-function screening using shRNA libraries is a powerful way to identify genes involved in almost any biological process. Over the past decade, shRNA screens, both in vivo and in cell culture systems, have generated many important discoveries... Read More ›
Research Trend
Controlling when and where: Conditional and inducible gene expression
In the early days of engineered animal models, simple knockout and transgenic mice were used to examine gene function. Researchers began to dissect the roles of individual genes by studying phenotypes of mice lacking or overexpressing specific genes... Read More ›
Research Trend
Optogenetics: Light-control of genes, pathways, and cells
Optogenenetics refers to a family of techniques which allow modulation of biological processes using light. Over the past 12 years, optogenetics has revolutionized neuroscience and is now expanding to impact many fields of biology. There are now... Read More ›
Breaking News
CRISPR causes unexpected and widespread mutations in vivo
Nuclease-mediated genome editing, using TALEN or CRISPR/Cas9, has exploded onto the scene in recent years, with hundreds of research papers and patents being published. These technologies hold great promise for treating a wide range of diseases by... Read More ›
You can order various molecular cloning services through Design My Vector or Send Design Request on the homepage. You can find our available services and products on the menu bar.
Please let us know what you would like to hear from us about the latest technologies or discoveries by leaving a feedback or contacting us.