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Vectors for Human ACTN4

Gene Information

  • Offical Gene Symbol ACTN4
  • Species Human (Homo sapiens)
  • Offical Full Name actinin alpha 4
  • Other Aliases ACTININ-4; FSGS; FSGS1
  • Other Desigations alpha-actinin-4; focal segmental glomerulosclerosis 1; non-muscle alpha-actinin 4
  • Gene Type protein-coding
  • Summary
    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
  • NCBI Gene ID 81
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human ACTN4(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACTN4 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human ACTN4 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human ACTN4 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human ACTN4 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human ACTN4 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACTN4 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human ACTN4 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Human ACTN4 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Human ACTN4 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACTN4 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human ACTN4 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Human ACTN4 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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