Vectors for Human ACY1

Gene Information

  • Offical Gene Symbol ACY1
  • Species Human ( Homo sapiens )
  • Offical Full Name aminoacylase 1
  • Other Aliases ACY-1; ACY1D; HEL-S-5
  • Other Desigations aminoacylase-1; N-acyl-L-amino-acid amidohydrolase; acylase; epididymis secretory protein Li 5
  • Gene Type protein-coding
  • Summary
    This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
  • NCBI Gene ID 95
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

Popular Vector Designs for Human ACY1(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACY1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human ACY1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human ACY1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human ACY1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human ACY1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACY1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human ACY1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $99
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Human ACY1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human ACY1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACY1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human ACY1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   $99
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Human ACY1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   $239
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