Vectors for Human ADD3

Gene Information

  • Offical Gene Symbol ADD3
  • Species Human ( Homo sapiens )
  • Offical Full Name adducin 3
  • Other Aliases ADDL; CPSQ3
  • Other Desigations gamma-adducin; adducin 3 (gamma); adducin-like protein 70
  • Gene Type protein-coding
  • Summary
    Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
  • NCBI Gene ID 120
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

Popular Vector Designs for Human ADD3(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ADD3 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human ADD3 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human ADD3 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human ADD3 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human ADD3 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ADD3 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human ADD3 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $99
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Human ADD3 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human ADD3 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ADD3 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human ADD3 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   $99
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Human ADD3 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   $239
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