Vectors for Human APOB

Gene Information

  • Offical Gene Symbol APOB
  • Species Human (Homo sapiens)
  • Offical Full Name apolipoprotein B
  • Other Aliases FCHL2; FLDB; LDLCQ4; apoB-100; apoB-48
  • Other Desigations apolipoprotein B-100; apolipoprotein B (including Ag(x) antigen); apolipoprotein B48
  • Gene Type protein-coding
  • Summary
    This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL), and is the ligand for the LDL receptor. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Dec 2019]
  • NCBI Gene ID 338
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human APOB(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human APOB expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human APOB expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human APOB expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human APOB expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human APOB expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human APOB shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
View Vector 
Human APOB shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
View Vector 
Human APOB shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human APOB shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human APOB CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human APOB CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human APOB CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
View Vector 

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