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Vectors for Human BBC3

Gene Information

  • Offical Gene Symbol BBC3
  • Species Human (Homo sapiens)
  • Offical Full Name BCL2 binding component 3
  • Other Aliases JFY-1; JFY1; PUMA
  • Other Desigations bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; p53-upregulated modulator of apoptosis
  • Gene Type protein-coding
  • Summary
    This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
  • NCBI Gene ID 27113
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human BBC3(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BBC3 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human BBC3 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human BBC3 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human BBC3 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human BBC3 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BBC3 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human BBC3 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human BBC3 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human BBC3 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BBC3 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human BBC3 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human BBC3 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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