Vectors for Human BCR

Gene Information

  • Offical Gene Symbol BCR
  • Species Human (Homo sapiens)
  • Offical Full Name BCR activator of RhoGEF and GTPase
  • Other Aliases ALL; BCR1; CML; D22S11; D22S662; PHL
  • Other Desigations breakpoint cluster region protein; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; FGFR1/BCR chimera protein; breakpoint cluster region; renal carcinoma antigen NY-REN-26
  • Gene Type protein-coding
  • Summary
    A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
  • NCBI Gene ID 613
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human BCR(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BCR expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human BCR expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human BCR expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human BCR expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human BCR expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BCR shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human BCR shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human BCR shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human BCR shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BCR CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human BCR CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human BCR CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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