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Vectors for Human BTRC

Gene Information

  • Offical Gene Symbol BTRC
  • Species Human (Homo sapiens)
  • Offical Full Name beta-transducin repeat containing E3 ubiquitin protein ligase
  • Other Aliases BETA-TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
  • Other Desigations F-box/WD repeat-containing protein 1A; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; beta-TrCP1; epididymis tissue protein Li 2a; pIkappaBalpha-E3 receptor subunit
  • Gene Type protein-coding
  • Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
  • NCBI Gene ID 8945
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human BTRC(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BTRC expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human BTRC expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human BTRC expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human BTRC expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human BTRC expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BTRC shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human BTRC shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human BTRC shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human BTRC shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human BTRC CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human BTRC CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human BTRC CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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