Vectors for Human COL18A1

Gene Information

  • Offical Gene Symbol COL18A1
  • Species Human (Homo sapiens)
  • Offical Full Name collagen type XVIII alpha 1 chain
  • Other Aliases GLCC; KNO; KNO1; KS
  • Other Desigations collagen alpha-1(XVIII) chain; antiangiogenic agent; collagen, type XVIII, alpha 1; endostatin; multi-functional protein MFP
  • Gene Type protein-coding
  • Summary
    This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] Annotation information: Annotation category: suggests misassembly
  • NCBI Gene ID 80781
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human COL18A1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL18A1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human COL18A1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human COL18A1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human COL18A1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human COL18A1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL18A1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human COL18A1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $269
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Human COL18A1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human COL18A1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL18A1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human COL18A1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human COL18A1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $269
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