Vectors for Human COL25A1

Gene Information

  • Offical Gene Symbol COL25A1
  • Species Human (Homo sapiens)
  • Offical Full Name collagen type XXV alpha 1 chain
  • Other Aliases AMY; CFEOM5; CLAC; CLAC-P; CLACP
  • Other Desigations collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component
  • Gene Type protein-coding
  • Summary
    This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • NCBI Gene ID 84570
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human COL25A1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL25A1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human COL25A1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human COL25A1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human COL25A1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human COL25A1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL25A1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human COL25A1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $269
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Human COL25A1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human COL25A1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL25A1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human COL25A1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human COL25A1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $269
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