Vectors for Human COL4A1

Gene Information

  • Offical Gene Symbol COL4A1
  • Species Human (Homo sapiens)
  • Offical Full Name collagen type IV alpha 1 chain
  • Other Aliases BSVD; BSVD1; COL4A1s; PADMAL; RATOR
  • Other Desigations collagen alpha-1(IV) chain; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, alpha-1 chain
  • Gene Type protein-coding
  • Summary
    This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
  • NCBI Gene ID 1282
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human COL4A1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL4A1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human COL4A1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human COL4A1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human COL4A1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human COL4A1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL4A1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human COL4A1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $269
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Human COL4A1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human COL4A1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL4A1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human COL4A1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human COL4A1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $269
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