Vectors for Human COL6A3

Gene Information

  • Offical Gene Symbol COL6A3
  • Species Human (Homo sapiens)
  • Offical Full Name collagen type VI alpha 3 chain
  • Other Aliases BTHLM1; DYT27; UCMD1
  • Other Desigations collagen alpha-3(VI) chain; collagen VI, alpha-3 polypeptide; collagen, type VI, alpha 3; epididymis secretory sperm binding protein
  • Gene Type protein-coding
  • Summary
    This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described. [provided by RefSeq, Jun 2009]
  • NCBI Gene ID 1293
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human COL6A3(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL6A3 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human COL6A3 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human COL6A3 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human COL6A3 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human COL6A3 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL6A3 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human COL6A3 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $269
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Human COL6A3 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human COL6A3 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human COL6A3 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human COL6A3 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human COL6A3 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $269
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