Human CSTB (Gene ID: 1476) vectors - Lentivirus, AAV, shRNA & CRISPR I VectorBuilder

Gene Information

Offical Gene Symbol CSTB
Species Human (Homo sapiens)
Offical Full Name cystatin B
Other Aliases CPI-B; CST6; EPM1; EPM1A; PME; STFB; ULD
Other Desigations cystatin-B; cystatin B (stefin B); epididymis secretory sperm binding protein; liver thiol proteinase inhibitor
Gene Type protein-coding
Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
NCBI Gene ID 1476
RefSeq Transcript
NM_000100.4
RefSeq Protein
NP_000091.1
External Links NCBI | OMIM | Ensembl | HGNC | UCSC Genome Browser View
View ORF sequence of this gene »

Vector Description	Vector Type	Price
Human CSTB expression regular plasmid vector	Mammalian Gene Expression Vector Guide	From $189
Human CSTB expression lentivirus vector	Mammalian Gene Expression Lentiviral Vector Guide	From $189
Human CSTB expression adenovirus vector	Mammalian Gene Expression Adenoviral Vector Guide	From $189
Human CSTB expression AAV vector	Mammalian Gene Expression AAV Vector Guide	From $189
Human CSTB expression PiggyBac vector	Mammalian Gene Expression PiggyBac Vector Guide	From $189

Vector Description	Vector Type	Price
Human CSTB shRNA lentivirus vector	Mammalian shRNA Knockdown Lentiviral Vector Guide	$149	View Vector
Human CSTB shRNA adenovirus vector	Mammalian shRNA Knockdown Adenoviral Vector Guide	$299	View Vector
Human CSTB shRNA AAV vector	Mammalian shRNA Knockdown AAV Vector Guide	$149	View Vector
Human CSTB shRNA PiggyBac vector	Mammalian shRNA Knockdown PiggyBac Vector Guide	$149	View Vector

Vector Description	Vector Type	Price
Human CSTB CRISPR regular plasmid vector	Mammalian CRISPR Vector (Single gRNA) Guide	$149	View Vector
Human CSTB CRISPR lentivirus vector	Mammalian CRISPR Lentiviral Vector (Single gRNA) Guide	$149	View Vector
Human CSTB CRISPR adenovirus vector	Mammalian CRISPR Adenoviral Vector (Single gRNA) Guide	$299	View Vector

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