Vectors for Human CXXC4

Gene Information

  • Offical Gene Symbol CXXC4
  • Species Human (Homo sapiens)
  • Offical Full Name CXXC finger protein 4
  • Other Aliases IDAX
  • Other Desigations CXXC-type zinc finger protein 4; CXXC finger 4; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); inhibition of the Dvl and axin complex protein
  • Gene Type protein-coding
  • Summary
    This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • NCBI Gene ID 80319
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human CXXC4(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human CXXC4 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human CXXC4 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human CXXC4 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human CXXC4 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human CXXC4 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human CXXC4 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
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Human CXXC4 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $269
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Human CXXC4 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human CXXC4 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human CXXC4 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
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Human CXXC4 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $99
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Human CXXC4 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $269
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