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Vectors for Human DDHD1

Gene Information

  • Offical Gene Symbol DDHD1
  • Species Human (Homo sapiens)
  • Offical Full Name DDHD domain containing 1
  • Other Aliases PA-PLA1; PAPLA1; SPG28; iPLA1I; iPLA1alpha
  • Other Desigations phospholipase DDHD1; intracellular phospholipase A1 alpha; phosphatidic acid-preferring phospholipase A1 homolog; phosphatidic acid-preferring phospholipase A1-like protein; phospholipid sn-1 acylhydrolase; spastic paraplegia 28 (autosomal recessive)
  • Gene Type protein-coding
  • Summary
    This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
  • NCBI Gene ID 80821
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human DDHD1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human DDHD1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human DDHD1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human DDHD1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human DDHD1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human DDHD1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human DDHD1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human DDHD1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human DDHD1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human DDHD1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human DDHD1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human DDHD1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human DDHD1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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