Vectors for Human GCH1

Gene Information

  • Offical Gene Symbol GCH1
  • Species Human (Homo sapiens)
  • Offical Full Name GTP cyclohydrolase 1
  • Other Aliases DYT14; DYT5; DYT5a; GCH; GTP-CH-1; GTPCH1; HPABH4B
  • Other Desigations GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I; dystonia 14; guanosine 5'-triphosphate cyclohydrolase I
  • Gene Type protein-coding
  • Summary
    This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
  • NCBI Gene ID 2643
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human GCH1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human GCH1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human GCH1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human GCH1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human GCH1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human GCH1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human GCH1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human GCH1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human GCH1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human GCH1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human GCH1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human GCH1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human GCH1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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