Vectors for Human MAP3K8

Gene Information

  • Offical Gene Symbol MAP3K8
  • Species Human (Homo sapiens)
  • Offical Full Name mitogen-activated protein kinase kinase kinase 8
  • Other Aliases AURA2; COT; EST; ESTF; MEKK8; TPL2; Tpl-2; c-COT
  • Other Desigations mitogen-activated protein kinase kinase kinase 8; Ewing sarcoma transformant; augmented in rheumatoid arthritis 2; cot (cancer Osaka thyroid) oncogene; proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; tumor progression locus 2
  • Gene Type protein-coding
  • Summary
    This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
  • NCBI Gene ID 1326
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human MAP3K8(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MAP3K8 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human MAP3K8 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human MAP3K8 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human MAP3K8 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human MAP3K8 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MAP3K8 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human MAP3K8 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human MAP3K8 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human MAP3K8 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MAP3K8 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human MAP3K8 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human MAP3K8 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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