Click to refer colleagues and get 30% off
  1. Home
  2. Find Popular Vectors
  3. Vectors for Human MDM4

Vectors for Human MDM4

Gene Information

  • Offical Gene Symbol MDM4
  • Species Human (Homo sapiens)
  • Offical Full Name MDM4 regulator of p53
  • Other Aliases BMFS6; HDMX; MDMX; MRP1
  • Other Desigations protein Mdm4; MDM4, p53 regulator; MDM4-related protein 1; Mdm4 p53 binding protein homolog; double minute 4, human homolog of; p53-binding protein; mdm2-like p53-binding protein; protein Mdmx
  • Gene Type protein-coding
  • Summary
    This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter\'s degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
  • NCBI Gene ID 4194
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human MDM4(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MDM4 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human MDM4 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human MDM4 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human MDM4 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human MDM4 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MDM4 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human MDM4 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Human MDM4 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Human MDM4 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MDM4 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human MDM4 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Human MDM4 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

Can’t find desired vectors above? Use options below to obtain custom vectors.

Design My Vector

Use this option to design your vector using our online platform.

You can request cloning & virus packaging services for your vector here.

Request Design Support

Use this option to ask our scientists to design your vector for free.

You can also submit other service inquires here, including:

  • Virus packaging
  • CRISPR targeting
  • BAC modification
  • Library construction
  • Plasmid DNA Preparation
  • RNA preparation
  • Mutagenesis
  • and more...