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Vectors for Human MET

Gene Information

  • Offical Gene Symbol MET
  • Species Human (Homo sapiens)
  • Offical Full Name MET proto-oncogene, receptor tyrosine kinase
  • Other Aliases AUTS9; DA11; DFNB97; HGFR; RCCP2; c-Met
  • Other Desigations hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met
  • Gene Type protein-coding
  • Summary
    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
  • NCBI Gene ID 4233
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human MET(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MET expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human MET expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human MET expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human MET expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human MET expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MET shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human MET shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human MET shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human MET shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MET CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human MET CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human MET CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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