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Vectors for Human NCF4

Gene Information

  • Offical Gene Symbol NCF4
  • Species Human (Homo sapiens)
  • Offical Full Name neutrophil cytosolic factor 4
  • Other Aliases CGD3; NCF; P40PHOX; SH3PXD4
  • Other Desigations neutrophil cytosol factor 4; NCF-4; SH3 and PX domain-containing protein 4; neutrophil NADPH oxidase factor 4; neutrophil cytosolic factor 4, 40kDa; p40-phox
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • NCBI Gene ID 4689
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human NCF4(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human NCF4 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human NCF4 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human NCF4 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human NCF4 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human NCF4 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human NCF4 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human NCF4 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Human NCF4 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Human NCF4 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human NCF4 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human NCF4 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Human NCF4 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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