Human PSEN2 (Gene ID: 5664) vectors - Lentivirus, AAV, shRNA & CRISPR I VectorBuilder

Gene Information

Offical Gene Symbol PSEN2
Species Human (Homo sapiens)
Offical Full Name presenilin 2
Other Aliases AD3L; AD4; CMD1V; PS2; STM2
Other Desigations presenilin-2; AD3LP; AD5; Alzheimer disease 3-like; Alzheimer disease 4; E5-1; PS-2; STM-2
Gene Type protein-coding
Summary
Alzheimer\'s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
NCBI Gene ID 5664
RefSeq Transcript
NM_000447.3; NM_012486.3
RefSeq Protein
NP_000438.2; NP_036618.2
External Links NCBI | OMIM | Ensembl | HGNC | UCSC Genome Browser View
View ORF sequence of this gene »

Vector Description	Vector Type	Price
Human PSEN2 expression regular plasmid vector	Mammalian Gene Expression Vector Guide	From $189
Human PSEN2 expression lentivirus vector	Mammalian Gene Expression Lentiviral Vector Guide	From $189
Human PSEN2 expression adenovirus vector	Mammalian Gene Expression Adenoviral Vector Guide	From $189
Human PSEN2 expression AAV vector	Mammalian Gene Expression AAV Vector Guide	From $189
Human PSEN2 expression PiggyBac vector	Mammalian Gene Expression PiggyBac Vector Guide	From $189

Vector Description	Vector Type	Price
Human PSEN2 shRNA lentivirus vector	Mammalian shRNA Knockdown Lentiviral Vector Guide	$149	View Vector
Human PSEN2 shRNA adenovirus vector	Mammalian shRNA Knockdown Adenoviral Vector Guide	$299	View Vector
Human PSEN2 shRNA AAV vector	Mammalian shRNA Knockdown AAV Vector Guide	$149	View Vector
Human PSEN2 shRNA PiggyBac vector	Mammalian shRNA Knockdown PiggyBac Vector Guide	$149	View Vector

Vector Description	Vector Type	Price
Human PSEN2 CRISPR regular plasmid vector	Mammalian CRISPR Vector (Single gRNA) Guide	$149	View Vector
Human PSEN2 CRISPR lentivirus vector	Mammalian CRISPR Lentiviral Vector (Single gRNA) Guide	$149	View Vector
Human PSEN2 CRISPR adenovirus vector	Mammalian CRISPR Adenoviral Vector (Single gRNA) Guide	$299	View Vector

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