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Vectors for Human PSTPIP1

Gene Information

  • Offical Gene Symbol PSTPIP1
  • Species Human (Homo sapiens)
  • Offical Full Name proline-serine-threonine phosphatase interacting protein 1
  • Other Aliases CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
  • Other Desigations proline-serine-threonine phosphatase-interacting protein 1; CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; PEST phosphatase-interacting protein 1
  • Gene Type protein-coding
  • Summary
    This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
  • NCBI Gene ID 9051
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human PSTPIP1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human PSTPIP1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human PSTPIP1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human PSTPIP1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human PSTPIP1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human PSTPIP1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human PSTPIP1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human PSTPIP1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human PSTPIP1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human PSTPIP1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human PSTPIP1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human PSTPIP1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human PSTPIP1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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