Vectors for Human TLR4

Gene Information

  • Offical Gene Symbol TLR4
  • Species Human (Homo sapiens)
  • Offical Full Name toll like receptor 4
  • Other Aliases ARMD10; CD284; TLR-4; TOLL
  • Other Desigations toll-like receptor 4; hToll; homolog of Drosophila toll; toll like receptor 4 protein
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
  • NCBI Gene ID 7099
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human TLR4(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human TLR4 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human TLR4 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human TLR4 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human TLR4 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human TLR4 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human TLR4 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
View Vector 
Human TLR4 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
View Vector 
Human TLR4 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
View Vector 
Human TLR4 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human TLR4 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
View Vector 
Human TLR4 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
View Vector 
Human TLR4 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
View Vector 

Can’t find desired vectors above? Use options below to obtain custom vectors.

Design My Vector

Use this option to design your vector using our online platform.

You can request cloning & virus packaging services for your vector here.

Request Design Support

Use this option to ask our scientists to design your vector for free.

You can also submit other service inquires here, including:

  • Virus packaging
  • CRISPR targeting
  • BAC modification
  • Library construction
  • Plasmid DNA Preparation
  • RNA preparation
  • Mutagenesis
  • and more...