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Vectors for Lesser hedgehog tenrec OAZ3

Gene Information

  • Offical Gene Symbol OAZ3
  • Species Lesser hedgehog tenrec (Echinops telfairi)
  • Offical Full Name -
  • Other Aliases -
  • Other Desigations ornithine decarboxylase antizyme 3
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014]
  • NCBI Gene ID 101641802
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI UCSC Genome Browser View

Popular Vector Designs for Lesser hedgehog tenrec OAZ3(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Lesser hedgehog tenrec OAZ3 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Lesser hedgehog tenrec OAZ3 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Lesser hedgehog tenrec OAZ3 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Lesser hedgehog tenrec OAZ3 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Lesser hedgehog tenrec OAZ3 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189

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