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Vectors for Mouse Srebf1

Gene Information

  • Offical Gene Symbol Srebf1
  • Species Mouse (Mus musculus)
  • Offical Full Name sterol regulatory element binding transcription factor 1
  • Other Aliases ADD1; SREBP1; bHLHd1
  • Other Desigations sterol regulatory element-binding protein 1; adipocyte determination- and differentiation-dependent factor 1
  • Gene Type protein-coding
  • Summary
    This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]
  • NCBI Gene ID 20787
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Mouse Srebf1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Srebf1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Mouse Srebf1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Mouse Srebf1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Mouse Srebf1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Mouse Srebf1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Srebf1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Mouse Srebf1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Mouse Srebf1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Mouse Srebf1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Srebf1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Mouse Srebf1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Mouse Srebf1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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