Vectors for Western clawed frog azin1

Gene Information

  • Offical Gene Symbol azin1
  • Species Western clawed frog (Xenopus tropicalis)
  • Offical Full Name antizyme inhibitor 1
  • Other Aliases oazin
  • Other Desigations antizyme inhibitor 1
  • Summary
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]
  • NCBI Gene ID 493320
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI

Popular Vector Designs for Western clawed frog azin1(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Western clawed frog azin1 expression regular plasmid vector Mammalian Gene Expression Vector EGFP/Puro From $159
Western clawed frog azin1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector EGFP:T2A:Puro From $159
Western clawed frog azin1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector EGFP From $159
Western clawed frog azin1 expression AAV vector Mammalian Gene Expression AAV Vector EGFP From $159
Western clawed frog azin1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector EGFP/Puro From $159

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