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Technical Bulletin

From fibroblast to blastocyst: the magic ingredients
Latest Discovery
From fibroblast to blastocyst: the magic ingredients
When the lab of Shinya Yamanaka revealed that viral introduction of Oct3/4, Sox2, Klf4 and c-Myc (OSKM) into adult skin cells could transform them into induced pluripotent stem cells (iPSCs), the world quickly took notice at the prospect of using iP... Read More ››
CRISPRing our cellular roots
Research Trend
CRISPRing our cellular roots
The remarkable process by which a single totipotent zygote develops into the approximately 37 trillion cells in a human body is orchestrated by a highly controlled sequence of signaling events resulting in a multitude of differentiated cell types. Th... Read More ››
AAVs usher in the new era of Gene Therapy
Research Trend
AAVs usher in the new era of Gene Therapy
Adeno-associated virus (AAV), initially discovered as a contaminant of adenovirus preparations (1), is the choice vehicle for gene therapy due to its ability to transduce proliferating and non-dividing cells with no known pathogenicity to humans. As... Read More ››
AAV – The king of viral vectors?
Research Trend
AAV – The king of viral vectors?
Adeno-associated virus (AAV) has recently been surging in popularity as a vector system. The recent wave of gene therapy successes and powerful new genome editing technologies, such as CRISPR/Cas9, have increased public and scientific awareness of t... Read More ››
Vectors on the brain
Research Trend
Vectors on the brain
The nervous system presents several unique challenges that make it a difficult system to study experimentally. At a structural level, the brain has a complexity that is orders of magnitude greater than other organs, and even the peripheral nervous s... Read More ››
Optogenetics in the clinic
Research Trend
Optogenetics in the clinic
Ever since the cloning of channelrhodopsin-2 (ChR2), there has been an explosion of interest in applying optogenetic methods to all aspects of neuroscience1. Initially, ChR2 was used to control neuronal activity in vitro2,3, and shortly thereafter in... Read More ››
Lentivirus “cure” for an ALD
Research Trend
Lentivirus “cure” for an ALD
For decades, new innovations in stem cell biology and genetic manipulation have driven a wave of proposed treatments based on these technologies. Although there has been intense speculation and expectation about when and how these methods will finall... Read More ››
Treating alcoholism with gene therapy
Latest Discovery
Treating alcoholism with gene therapy
Alcoholism is a complex disease affecting hundreds of millions of people worldwide1. Despite having devastating consequences on physical and mental health, and indirectly impacting families and society, treatment options are limited and often ineffec... Read More ››
In vivo reprogramming with viral vectors
Research Trend
In vivo reprogramming with viral vectors
Although multicellular organisms are made up of many cell types, all with essentially identical genomes, cells rarely interconvert between cell types. Once a cell acquires a specific cell fate, it generally does not assume the phenotype of an alternate cell type.... Read More ››
shRNA screens lead to major discoveries
Research Trend
shRNA screens lead to major discoveries
Loss-of-function screening using shRNA libraries is a powerful way to identify genes involved in almost any biological process. Over the past decade, shRNA screens, both in vivo and in cell culture systems, have generated many important discoveries... Read More ››
Controlling when and where: conditional and inducible gene expression
Research Trend
Controlling when and where: conditional and inducible gene expression
In the early days of engineered animal models, simple knockout and transgenic mice were used to examine gene function. Researchers began to dissect the roles of individual genes by studying phenotypes of mice lacking or overexpressing specific genes... Read More ››
Optogenetics: light-control of genes, pathways, and cells
Research Trend
Optogenetics: light-control of genes, pathways, and cells
Optogenenetics refers to a family of techniques which allow modulation of biological processes using light. Over the past 12 years, optogenetics has revolutionized neuroscience and is now expanding to impact many fields of biology. There are now... Read More ››
CRISPR causes unexpected and widespread mutations <i> in vivo</i>
Breaking News
CRISPR causes unexpected and widespread mutations in vivo
Nuclease-mediated genome editing, using TALEN or CRISPR/Cas9, has exploded onto the scene in recent years, with hundreds of research papers and patents being published. These technologies hold great promise for treating a wide range of diseases by... Read More ››
CRISPR-based unicellular computer
Latest Discovery
CRISPR-based unicellular computer
A major goal of synthetic biology is to design and build digital genetic circuits inside cells, effectively programming cellular functions. Achieved this could allow living cells to be engineered to perform decision-making tasks, similar to computer... Read More ››
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