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Vector Academy

Vector Academy is our knowledge base that serves as your resource for diving deeper into all things cloning, viruses, and gene delivery. We’re excited to share our expertise and what we’ve learned from decades of collective experience with you.
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Unleashing the Power of Oncolytic Viruses: Design Strategies for Maximum Efficacy

Keywords: Oncolytic virus, tumor targeting, immune stimulation

A deep dive into the attributes and design of recombinant viruses for use as potent oncolytic agents in the clinic and why HSV and VACV are ideal oncolytic virus candidates.

Driving CAR-T Therapy in the Clinic and with CRISPR

Keywords: CAR-T cell therapy, Kymriah CAR-T, immunotherpy

A deep dive into the biology behind CAR-T vectors, their clinical applications, and how CRISPR/Cas9 is being used to create the next generation of CAR therapeutics.

Unveiling the Versatility of Vesicular Stomatitis Virus: Pseudotyping and Beyond

Keywords: VSV immunotherapy, oncolytic virus, pseudotyping

Vesicular stomatitis virus (VSV), known for its simplicity and well-explored biology, serves as an invaluable model in virology, particularly through pseudotyping, where its envelope protein is swapped with that of another virus.

So Many Viral Options. How Do You Choose?

Keywords: Viral gene therapy, retrovirus, transient transfection

A comprehensive guide to selecting the appropriate viral vector for gene delivery experiments. The article examines how factors such as cell type, expression type, and insert size can impact your experiment while comparing the integration capabilities, carrying capacities, and tropisms of different viruses.

No SMAll Feat

Keywords: Zolgensma mechanism, spinal muscular atrophy

Learn about spinal muscular atrophy from a genetic perspective and the mechanisms behind two key gene therapy treatments, Spinraza and Zolgensma.

Beta Late Than Never

Keywords: Zynteglo gene therapy, beta thalassemia

Learn about the genetic blood disorder beta thalassemia and the lentiviral and CRISPR/Cas9-based gene therapy approaches for treatment.

GLAd to Be Treating DMD

Keywords: Muscular dystrophy, gutless adenovirus, gene therapy

Learn about exciting gene therapy approaches utilizing AAV, adenovirus and gutless adenovirus for treating Duchenne muscular dystrophy.

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