Vectors for Human ABAT

Gene Information

  • Offical Gene Symbol ABAT
  • Species Human ( Homo sapiens )
  • Offical Full Name 4-aminobutyrate aminotransferase
  • Other Aliases GABA-AT; GABAT; NPD009
  • Other Desigations 4-aminobutyrate aminotransferase, mitochondrial; (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate transaminase; GABA aminotransferase; GABA transaminase; GABA transferase; gamma-amino-N-butyrate transaminase
  • Gene Type protein-coding
  • Summary
    4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • NCBI Gene ID 18
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

Popular Vector Designs for Human ABAT(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ABAT expression regular plasmid vector Mammalian Gene Expression Vector   Guide  EGFP/Puro From $159
Human ABAT expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  EGFP:T2A:Puro From $159
Human ABAT expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  EGFP From $159
Human ABAT expression AAV vector Mammalian Gene Expression AAV Vector   Guide  EGFP From $159
Human ABAT expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  EGFP/Puro From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ABAT shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  EGFP:T2A:Puro $99
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Human ABAT shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  EGFP $99
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Human ABAT shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  EGFP $99
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Human ABAT shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  EGFP:T2A:Puro $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ABAT CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  EGFP/Puro $99
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Human ABAT CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Puro $99
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Human ABAT CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   EGFP $239
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