Vectors for Human ADAM17

Gene Information

  • Offical Gene Symbol ADAM17
  • Species Human ( Homo sapiens )
  • Offical Full Name ADAM metallopeptidase domain 17
  • Other Aliases ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE
  • Other Desigations disintegrin and metalloproteinase domain-containing protein 17; ADAM metallopeptidase domain 18; TNF-alpha convertase; TNF-alpha converting enzyme; snake venom-like protease; tumor necrosis factor, alpha, converting enzyme
  • Gene Type protein-coding
  • Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn\'s disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
  • NCBI Gene ID 6868
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

Popular Vector Designs for Human ADAM17(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ADAM17 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human ADAM17 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human ADAM17 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human ADAM17 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human ADAM17 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ADAM17 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
View Vector 
Human ADAM17 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $99
View Vector 
Human ADAM17 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
View Vector 
Human ADAM17 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ADAM17 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
View Vector 
Human ADAM17 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   $99
View Vector 
Human ADAM17 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   $239
View Vector 

Can’t find desired vectors above? Use options below to obtain custom vectors.

Design My Vector

Use this option to design your vector using our online platform.

You can request cloning & virus packaging services for your vector here.

Send Design Request

Use this option to ask our scientists to design your vector for free.

You can also submit other service inquires here, including:

  • Virus packaging
  • CRISPR targeting
  • BAC modification
  • Library construction
  • Plasmid DNA preparation
  • RNA preparation
  • Mutagenesis
  • and more...