Vectors for Alpaca AZIN2

Gene Information

  • Offical Gene Symbol AZIN2
  • Species Alpaca (Vicugna pacos)
  • Offical Full Name -
  • Other Aliases ADC
  • Other Desigations antizyme inhibitor 2; arginine decarboxylase
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). [provided by RefSeq, Sep 2014]
  • NCBI Gene ID 102534623
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI

Popular Vector Designs for Alpaca AZIN2(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Alpaca AZIN2 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  EGFP/Puro From $159
Alpaca AZIN2 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  EGFP:T2A:Puro From $159
Alpaca AZIN2 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  EGFP From $159
Alpaca AZIN2 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  EGFP From $159
Alpaca AZIN2 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  EGFP/Puro From $159

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