Technical Bulletin

Research Trend
Novel oncogenic fusion discovered and classified in pheochromocytoma
Pheochromocytoma is a rare tumor that develops in the adrenal glands. To discover novel driver events of the disease, Dr. Patricia Dahia and her team at the University of Texas San Antonio Division of Hematology and Medical Oncology conducted whole... Read More ››
Interesting Story
Single dose of off-the-shelf gene therapy boosts the immune system to fight cancer
One of the major challenges in the clinic for the treatment of various diseases is the ability to consistently deliver therapeutics at efficacious levels. Recently, researchers in the Division of Hematology and Oncology at Nationwide Children’s Hos... Read More ››
Research Trend
Gold labeled antibody fragments provide insight into the senses
Stereocilia are important structures found in the inner ear that are involved in hearing and balance. Recently, scientists at the Vollum Institute at the Oregon Health and Science University were able to provide insight into the structure and confo... Read More ››
Interesting Story
Molecular barcodes offer insight into cancer
New advances in molecular barcoding offer exciting possibilities, especially in cancer research. Over the years, molecular barcoding involved generating specific nucleic acids or proteins within cells to trace lineages across generations to observe... Read More ››
Breaking News
SARS-CoV-2 variants: Human antibody-mediated immunity or Harry Houdini?
The pandemic COVID-19 has caused over 2 million deaths globally with the numbers increasing at an alarming rate. A monumental worldwide vaccination program is being rolled out with several companies including AstraZeneca/Oxford University, Pfizer/Bi... Read More ››
Latest Discovery
A real breakthrough for Parkinson’s disease?
One of the greatest barriers to treating neural degeneration and neural tissue injury is the fact that neurons do not proliferate, and there are only a few areas of the brain that exhibit neurogenesis. It is possible to convert one somatic cell type... Read More ››
Research Trend
A powerful mouse model for studying Covid-19
We have all been engulfed by the current SARS-CoV-2 pandemic with the lives of millions affected. To date, COVID-19 has resulted in almost 8 million confirmed cases with over 400,000 deaths. Considerable effort and money have been invested in trying... Read More ››
Breaking News
Coronavirus – How it began
During the beginning of this year, a novel coronavirus disease — termed Covid-19 by the WHO — was identified as being responsible for a sudden increase in cases of pneumonia in hospitalized patients. We have seen this rapidly escalate into a global... Read More ››
Latest Discovery
De-arming CRISPR/Cas9 to increase knock-in efficiency
The ability to knock in (KI) DNA sequences via homologous recombination (HR) to generate knockout (KO) mice was first demonstrated 30 years ago by Mario R. Capecchi, Martin J. Evans and Oliver Smithies (1,2). In recent years, CRISPR/Cas9 has revolut... Read More ››
Research Trend
A new scar reduction role for engineered T cells
Cardiovascular diseases (CVDs) are the number one cause of death globally, responsible for 31% of all human mortalities. This is in part due to lifestyle but also because the human heart is incapable of functional regeneration following injury or on... Read More ››
Interesting Story
The painless people
Wouldn’t it be nice if we felt no pain? Although lacking the ability to feel pain sounds tempting, considering we could have simply moved on with our lives without going through the hassle of tending to our injuries, the consequences of being painles... Read More ››
Latest Discovery
From fibroblast to blastocyst: the magic ingredients
When the lab of Shinya Yamanaka revealed that viral introduction of Oct3/4, Sox2, Klf4 and c-Myc (OSKM) into adult skin cells could transform them into induced pluripotent stem cells (iPSCs), the world quickly took notice at the prospect of using iP... Read More ››
Research Trend
CRISPRing our cellular roots
The remarkable process by which a single totipotent zygote develops into the approximately 37 trillion cells in a human body is orchestrated by a highly controlled sequence of signaling events resulting in a multitude of differentiated cell types. Th... Read More ››
Research Trend
AAVs usher in the new era of Gene Therapy
Adeno-associated virus (AAV), initially discovered as a contaminant of adenovirus preparations (1), is the choice vehicle for gene therapy due to its ability to transduce proliferating and non-dividing cells with no known pathogenicity to humans. As... Read More ››
Research Trend
AAV – The king of viral vectors?
Adeno-associated virus (AAV) has recently been surging in popularity as a vector system. The recent wave of gene therapy successes and powerful new genome editing technologies, such as CRISPR/Cas9, have increased public and scientific awareness of t... Read More ››
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