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Vectors for Cow DIO3

Gene Information

  • Offical Gene Symbol DIO3
  • Species Cow (Bos taurus)
  • Offical Full Name iodothyronine deiodinase 3
  • Other Aliases -
  • Other Desigations thyroxine 5-deiodinase; 5DIII; DIOIII; deiodinase, iodothyronine type III; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase
  • Gene Type protein-coding
  • Summary
    The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3\',5-triiodothyronine (T3) to inactive metabolites, 3,3\',5\'-triiodothyronine (RT3) and 3,3\'-diiodothyronine (T2), respectively. It is highly expressed in placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It thus plays a critical role in mammalian development by regulating circulating fetal thyroid hormone concentration. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3\' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]
  • NCBI Gene ID 494549
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Cow DIO3(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Cow DIO3 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Cow DIO3 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Cow DIO3 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Cow DIO3 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Cow DIO3 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189

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