Click to refer colleagues and get 30% off
  1. Home
  2. Find Popular Vectors
  3. Vectors for Human AZIN1

Vectors for Human AZIN1

Gene Information

  • Offical Gene Symbol AZIN1
  • Species Human (Homo sapiens)
  • Offical Full Name antizyme inhibitor 1
  • Other Aliases AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L
  • Other Desigations antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
  • NCBI Gene ID 51582
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human AZIN1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human AZIN1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human AZIN1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human AZIN1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human AZIN1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human AZIN1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human AZIN1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human AZIN1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Human AZIN1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Human AZIN1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human AZIN1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human AZIN1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Human AZIN1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

Can’t find desired vectors above? Use options below to obtain custom vectors.

Design My Vector

Use this option to design your vector using our online platform.

You can request cloning & virus packaging services for your vector here.

Request Design Support

Use this option to ask our scientists to design your vector for free.

You can also submit other service inquires here, including:

  • Virus packaging
  • CRISPR targeting
  • BAC modification
  • Library construction
  • Plasmid DNA Preparation
  • RNA preparation
  • Mutagenesis
  • and more...