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Vectors for Human MAPK8IP1

Gene Information

  • Offical Gene Symbol MAPK8IP1
  • Species Human (Homo sapiens)
  • Offical Full Name mitogen-activated protein kinase 8 interacting protein 1
  • Other Aliases IB1; JIP-1; JIP1; PRKM8IP
  • Other Desigations C-Jun-amino-terminal kinase-interacting protein 1; IB-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; PRKM8 interacting protein; islet-brain 1
  • Gene Type protein-coding
  • Summary
    This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
  • NCBI Gene ID 9479
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Human MAPK8IP1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MAPK8IP1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Human MAPK8IP1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Human MAPK8IP1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Human MAPK8IP1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Human MAPK8IP1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MAPK8IP1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
View Vector 
Human MAPK8IP1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
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Human MAPK8IP1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
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Human MAPK8IP1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MAPK8IP1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Human MAPK8IP1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
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Human MAPK8IP1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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