Human NPC1 (Gene ID: 4864) vectors - Lentivirus, AAV, shRNA & CRISPR I VectorBuilder

Gene Information

Offical Gene Symbol NPC1
Species Human (Homo sapiens)
Offical Full Name NPC intracellular cholesterol transporter 1
Other Aliases NPC; POGZ; SLC65A1
Other Desigations NPC intracellular cholesterol transporter 1; Niemann-Pick C1 protein
Gene Type protein-coding
Summary
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
NCBI Gene ID 4864
RefSeq Transcript
NM_000271.5
RefSeq Protein
NP_000262.2
External Links NCBI | OMIM | Ensembl | HGNC | UCSC Genome Browser View
View ORF sequence of this gene »

Vector Description	Vector Type	Price
Human NPC1 expression regular plasmid vector	Mammalian Gene Expression Vector Guide	From $189
Human NPC1 expression lentivirus vector	Mammalian Gene Expression Lentiviral Vector Guide	From $189
Human NPC1 expression adenovirus vector	Mammalian Gene Expression Adenoviral Vector Guide	From $189
Human NPC1 expression AAV vector	Mammalian Gene Expression AAV Vector Guide	From $189
Human NPC1 expression PiggyBac vector	Mammalian Gene Expression PiggyBac Vector Guide	From $189

Vector Description	Vector Type	Price
Human NPC1 shRNA lentivirus vector	Mammalian shRNA Knockdown Lentiviral Vector Guide	$149	View Vector
Human NPC1 shRNA adenovirus vector	Mammalian shRNA Knockdown Adenoviral Vector Guide	$299	View Vector
Human NPC1 shRNA AAV vector	Mammalian shRNA Knockdown AAV Vector Guide	$149	View Vector
Human NPC1 shRNA PiggyBac vector	Mammalian shRNA Knockdown PiggyBac Vector Guide	$149	View Vector

Vector Description	Vector Type	Price
Human NPC1 CRISPR regular plasmid vector	Mammalian CRISPR Vector (Single gRNA) Guide	$149	View Vector
Human NPC1 CRISPR lentivirus vector	Mammalian CRISPR Lentiviral Vector (Single gRNA) Guide	$149	View Vector
Human NPC1 CRISPR adenovirus vector	Mammalian CRISPR Adenoviral Vector (Single gRNA) Guide	$299	View Vector

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