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Vectors for Mouse Nelfb

Gene Information

  • Offical Gene Symbol Nelfb
  • Species Mouse (Mus musculus)
  • Offical Full Name negative elongation factor complex member B
  • Other Aliases A730008L03Rik; Cobra1; Nelf-b
  • Other Desigations negative elongation factor B; cofactor of BRCA1; negative elongation factor complex member B, Cobra1; ortholog of human cofactor of BRCA1 (COBRA1)
  • Gene Type protein-coding
  • Summary
    This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
  • NCBI Gene ID 58202
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | EnsemblUCSC Genome Browser View

Popular Vector Designs for Mouse Nelfb(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Nelfb expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Mouse Nelfb expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Mouse Nelfb expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Mouse Nelfb expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Mouse Nelfb expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Nelfb shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Mouse Nelfb shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Mouse Nelfb shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Mouse Nelfb shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Nelfb CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Mouse Nelfb CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Mouse Nelfb CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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