Vectors for Orangutan OAZ2

Gene Information

  • Offical Gene Symbol OAZ2
  • Species Orangutan (Pongo abelii)
  • Offical Full Name -
  • Other Aliases -
  • Other Desigations ornithine decarboxylase antizyme 2; AZ2; ODC-Az 2
  • NCBI Gene ID 100173592
  • Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014]
  • NCBI  | Ensembl

Pre-Designed Vectors for Orangutan OAZ2(These vectors can be made quickly)

Gene Expression Vector
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Pre-Vector Description Pre-Vector Type
Orangutan OAZ2 expression regular plasmid vector Regular plasmid gene expression vector
Orangutan OAZ2 expression lentivirus vector Lentivirus gene expression vector (3rd generation)
Orangutan OAZ2 expression adenovirus vector Adenovirus gene expression vector (1st generation)
Orangutan OAZ2 expression AAV vector Adeno-associated virus gene expression vector

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