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Vectors for Western clawed frog dio1

Gene Information

  • Offical Gene Symbol dio1
  • Species Western clawed frog (Xenopus tropicalis)
  • Offical Full Name deiodinase, iodothyronine type 1
  • Other Aliases -
  • Other Desigations type I iodothyronine deiodinase; deiodinase I; deiodinase, iodothyronine, type I; type 1 deiodinase
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3\',5\'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3\'-triiodothyronine, T3) by 5\'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3\' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
  • NCBI Gene ID 100497874
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Western clawed frog dio1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Western clawed frog dio1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Western clawed frog dio1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Western clawed frog dio1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Western clawed frog dio1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Western clawed frog dio1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189

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