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Vectors for Cow GPX1

Gene Information

  • Offical Gene Symbol GPX1
  • Species Cow (Bos taurus)
  • Offical Full Name glutathione peroxidase 1
  • Other Aliases -
  • Other Desigations glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; phospholipid-hydroperoxide glutathione peroxidase GPX1
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3\' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. There is a direct correlation between the concentration of selenium and the activity of this enzyme in lactating cows, with the highest levels observed during the early stage of lactation, suggesting that the generation of reactive oxygen species was higher during this period compared to the late stage. [provided by RefSeq, Jul 2016]
  • NCBI Gene ID 281209
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Cow GPX1(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Cow GPX1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Cow GPX1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Cow GPX1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Cow GPX1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Cow GPX1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189

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