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Vectors for Cow GPX4

Gene Information

  • Offical Gene Symbol GPX4
  • Species Cow (Bos taurus)
  • Offical Full Name glutathione peroxidase 4
  • Other Aliases PHGPx
  • Other Desigations phospholipid hydroperoxide glutathione peroxidase; GPx-4; GSHPx-4; glutathione peroxidase 4 (phospholipid hydroperoxidase); phospholipid hydroperoxide glutathione peroxidase, mitochondrial
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3\' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
  • NCBI Gene ID 286809
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Cow GPX4(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Cow GPX4 expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Cow GPX4 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Cow GPX4 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Cow GPX4 expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Cow GPX4 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189

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