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Vectors for Mouse Alpl

Gene Information

  • Offical Gene Symbol Alpl
  • Species Mouse (Mus musculus)
  • Offical Full Name alkaline phosphatase, liver/bone/kidney
  • Other Aliases ALP; APTNAP; Akp-2; Akp2; TNAP; TNSALP
  • Other Desigations alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphatase 2, liver; phosphoamidase; phosphocreatine phosphatase
  • Gene Type protein-coding
  • Summary
    This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
  • NCBI Gene ID 11647
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Mouse Alpl(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Alpl expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Mouse Alpl expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Mouse Alpl expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Mouse Alpl expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Mouse Alpl expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Alpl shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
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Mouse Alpl shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
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Mouse Alpl shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
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Mouse Alpl shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Alpl CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
View Vector 
Mouse Alpl CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Mouse Alpl CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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