Vectors for Mouse Xist

Gene Information

Offical Gene Symbol Xist
Species Mouse (Mus musculus)
Offical Full Name inactive X specific transcripts
Other Aliases A430022B11
Other Desigations -
Gene Type ncRNA
Summary
X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome. It is essential for the initiation and spread of X-inactivation. It silences hundreds of genes by recruiting and tethering repressive chromatin-modifying complexes to the inactive X chromosome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
NCBI Gene ID 213742
RefSeq Transcript
NR_001463.3; NR_001570.2
RefSeq Protein
-; -
External Links NCBI | Ensembl | UCSC Genome Browser View
View ORF sequence of this gene »

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