HiExpress™ Firefly Luciferase GalNAc LNP-mRNA
Our HiExpress™ Firefly Luciferase GalNAc LNP-mRNA uses GalNAc-modified LNPs to target ASGPR receptors on hepatocytes, offering an alternative to traditional ApoE/LDLR binding for LNP uptake. Codon-optimized for robust gene expression, this product ensures effective delivery in both standard and Ldlr-/- mice strains.
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Shipping and storage
Our LNP-mRNA products are stored in Tris buffer (pH 7.4) and can be stored at -80°C for up to 6 months. The products are shipped on dry ice and should be avoided for freeze-thaw cycles.
Experimental Validation
Figure 1. Efficient hepatic delivery of mRNA in Ldlr−/− mice using a GalNAc-lipid nanoparticle (LNP). HiExpress™ Firefly Luciferase IVT mRNA made with m1Ψ was encapsulated with GalNAc or standard SM102-based LNP. Each wild-type or Ldlr knockout C57BL/6 mouse was intravenously administered via tail vein with 0.5 mg encapsulated RNA per kg of body weight. Luciferase activity was visualized by live imaging at 6 h and 24 h post-injection.
Documents
Brochures & Flyers
Certificate of Analysis (COA)
Material Safety Data Sheet (MSDS)
