Vectors for Human A2M

Gene Information

  • Offical Gene Symbol A2M
  • Species Human ( Homo sapiens )
  • Offical Full Name alpha-2-macroglobulin
  • Other Aliases A2MD; CPAMD5; FWP007; S863-7
  • Other Desigations alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-M
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer\'s disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
  • NCBI Gene ID 2
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

Pre-Made Vectors for Human A2M (These vectors are in stock and available immediately)

Gene Expression Vectors
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Name Vector Type Marker Price
pLV[Exp]-Puro-CMV>hA2M[NM_000014.4] Mammalian Gene Expression Lentiviral Vector   Guide  Puro $289 View Vector 

Popular Vector Designs for Human A2M(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human A2M expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $159
Human A2M expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $159
Human A2M expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $159
Human A2M expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $159
Human A2M expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human A2M shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $99
View Vector 
Human A2M shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $99
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Human A2M shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $99
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Human A2M shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human A2M CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $99
View Vector 
Human A2M CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   $99
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Human A2M CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   $239
View Vector 

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