Vectors for Human ACO1

Gene Information

  • Offical Gene Symbol ACO1
  • Species Human ( Homo sapiens )
  • Offical Full Name aconitase 1
  • Other Aliases ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
  • Other Desigations cytoplasmic aconitate hydratase; aconitase 1, soluble; aconitate hydratase, cytoplasmic; citrate hydro-lyase; cytoplasmic aconitase; cytosplasmic aconitase; epididymis luminal protein 60; epididymis secretory sperm binding protein; ferritin repressor protein; iron regulatory protein 1; iron-responsive element-binding protein 1; soluble aconitase
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5\' UTR of ferritin mRNA, and in the 3\' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
  • NCBI Gene ID 48
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNC

Popular Vector Designs for Human ACO1(These vectors can be made quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACO1 expression regular plasmid vector Mammalian Gene Expression Vector   Guide  EGFP/Puro From $159
Human ACO1 expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  EGFP:T2A:Puro From $159
Human ACO1 expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  EGFP From $159
Human ACO1 expression AAV vector Mammalian Gene Expression AAV Vector   Guide  EGFP From $159
Human ACO1 expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  EGFP/Puro From $159
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACO1 shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  EGFP:T2A:Puro $99
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Human ACO1 shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  EGFP $99
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Human ACO1 shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  EGFP $99
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Human ACO1 shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  EGFP:T2A:Puro $99
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human ACO1 CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  EGFP/Puro $99
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Human ACO1 CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Puro $99
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Human ACO1 CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   EGFP $239
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Pre-Made Vectors for Human ACO1 (These vectors are in stock and available immediately)

shRNA Knockdown Vectors
These pre-made vectors are constructed with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Name Vector Type Knockdown Score
Knockdown scores estimate the efficiency and specificity of shRNAs in knocking down target genes. Scores are calculated from a set of rules, and mostly range from 0 (worst) to 15 (best).
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Marker Price
pLV[shRNA]-EGFP:T2A:Puro-U6>hACO1[shRNA#1] Mammalian shRNA Knockdown Lentiviral Vector   Guide  13.2 EGFP:T2A:Puro $99 View Vector 

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