Vectors for Human MANF

Gene Information

  • Offical Gene Symbol MANF
  • Species Human (Homo sapiens)
  • Offical Full Name mesencephalic astrocyte derived neurotrophic factor
  • Other Aliases ARMET; ARP; DDDS
  • Other Desigations mesencephalic astrocyte-derived neurotrophic factor; arginine-rich, mutated in early stage tumors
  • Gene Type protein-coding
  • Summary
    The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
  • NCBI Gene ID 7873
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | OMIM  | Ensembl  | HGNCUCSC Genome Browser View

Popular Vector Designs for Human MANF(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MANF expression regular plasmid vector Mammalian Gene Expression Vector   Guide  From $189
Human MANF expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide  From $189
Human MANF expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide  From $189
Human MANF expression AAV vector Mammalian Gene Expression AAV Vector   Guide  From $189
Human MANF expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide  From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MANF shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide  $149
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Human MANF shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide  $299
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Human MANF shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide  $149
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Human MANF shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide  $149
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CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Human MANF CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide  $149
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Human MANF CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide  $149
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Human MANF CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide  $299
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