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Vectors for Mouse Hmgcr

Gene Information

  • Offical Gene Symbol Hmgcr
  • Species Mouse (Mus musculus)
  • Offical Full Name 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • Other Aliases HMG-CoAR; Red
  • Other Desigations 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; HMG-CoA reductase
  • Gene Type protein-coding
  • Summary
    Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within cholesterol biosynthetic process; negative regulation of MAP kinase activity; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; forelimb bud; and ganglia. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
  • NCBI Gene ID 15357
  • RefSeq Transcript
  • RefSeq Protein
  • External Links NCBI  | Ensembl |  UCSC Genome Browser View
  • View ORF sequence of this gene »

Questions

Popular Vector Designs for Mouse Hmgcr(These vectors can be made very quickly)

Gene Expression Vectors
These designs are created with VectorBuilder’s standard backbones containing a ubiquitous promoter driving the ORF of your gene. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Hmgcr expression regular plasmid vector Mammalian Gene Expression Vector   Guide 
From $189
Mouse Hmgcr expression lentivirus vector Mammalian Gene Expression Lentiviral Vector   Guide 
From $189
Mouse Hmgcr expression adenovirus vector Mammalian Gene Expression Adenoviral Vector   Guide 
From $189
Mouse Hmgcr expression AAV vector Mammalian Gene Expression AAV Vector   Guide 
From $189
Mouse Hmgcr expression PiggyBac vector Mammalian Gene Expression PiggyBac Vector   Guide 
From $189
shRNA Knockdown Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving an shRNA targeting your gene of interest. A marker (e.g. EGFP) is placed in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Hmgcr shRNA lentivirus vector Mammalian shRNA Knockdown Lentiviral Vector   Guide 
$149
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Mouse Hmgcr shRNA adenovirus vector Mammalian shRNA Knockdown Adenoviral Vector   Guide 
$299
View Vector 
Mouse Hmgcr shRNA AAV vector Mammalian shRNA Knockdown AAV Vector   Guide 
$149
View Vector 
Mouse Hmgcr shRNA PiggyBac vector Mammalian shRNA Knockdown PiggyBac Vector   Guide 
$149
View Vector 
CRISPR Vectors
These designs are created with VectorBuilder’s standard backbones containing a U6 promoter driving a gRNA targeting your gene of interest. A marker (e.g. EGFP) is place in the vector where appropriate.
Vector Description Vector Type Marker Price
Mouse Hmgcr CRISPR regular plasmid vector Mammalian CRISPR Vector (Single gRNA)   Guide 
$149
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Mouse Hmgcr CRISPR lentivirus vector Mammalian CRISPR Lentiviral Vector (Single gRNA)   Guide 
$149
View Vector 
Mouse Hmgcr CRISPR adenovirus vector Mammalian CRISPR Adenoviral Vector (Single gRNA)   Guide 
$299
View Vector 

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