VectorBuilder offers many popular vector components that users can choose from when designing their vectors. The tables below provide detailed information on these popular components, which are listed separately by category.
|CD3zeta||Intracellular domain of the T cell receptor-CD3ζ chain||Acts as a stimulatory molecule for activating T cell-mediated immune response.||Cell. 64:891 (1991); Nat Rev Immunol. 2:512 (2002); WO2014055771A1||View|
|CD28||CD28 intracellular costimulatory domain||Improves overall survival, proliferation and persistence of activated CAR-T cells.||Nat Biotechnol. 20:70 (2002); J Immunother. 32:689 (2009); WO2014055771A1||View|
|4-1BB||4-1BB intracellular costimulatory domain||Improves overall survival, proliferation and persistence of activated CAR-T cells; further enhances cytotoxicity and durability when used in combination with CD28.||Leukemia. 18:676 (2004); Mol Ther. 17:1453 (2009); EP2904106A2||View|