T-cell Signaling Domain

VectorBuilder offers many popular vector components that users can choose from when designing their vectors. The tables below provide detailed information on these popular components, which are listed separately by category.
Costimulatory Domain
Name Description Application Notes References Sequence
CD28 CD28 intracellular costimulatory domain Improves overall survival, proliferation and persistence of activated CAR-T cells. Nat Biotechnol. 20:70 (2002); J Immunother. 32:689 (2009); WO2014055771A1 View
4-1BB 4-1BB intracellular costimulatory domain Improves overall survival, proliferation and persistence of activated CAR-T cells; further enhances cytotoxicity and durability when used in combination with CD28. Leukemia. 18:676 (2004); Mol Ther. 17:1453 (2009); EP2904106A2 View